Hyperpolarized 13C magnetic resonance spectroscopy in pig models enables metabolic activity mapping, providing a powerful tool for the study of the heart physiology, but requires the development of dedicated radiofrequency coils, capable of providing large field of view with high signal-to-noise ratio (SNR) data. This work describes the simulations and the tests of a transmit-only (TX) volume coil/receive-only (RX) surface coil both designed for hyperpolarized studies of pig heart with a clinical 3T scanner. The coil characterization is performed by devel- oping an SNR model for coil performance in terms of coil resistance, sample- induced resistance and magnetic field pattern. In particular, coil resistances were calculated from Ohm’s law, while magnetic field patterns and sample-induced resistances were calculated using a numerical finite-difference time-algorithm. Experimental phantom chemical shift image, showed good agreement with the theoretical SNR-vs-depth profiles and highlighted the advantage of the novel configuration over the single transmit–receive coils throughout the volume of interest for cardiac imaging in pig. Finally, the TX-birdcage/RX-circular configu- ration was tested by acquiring metabolic maps with hyperpolarized [1-13C] pyru- vate injected i.v. in a pig. The results of the phantom and pig experiments show the ability of the coil configuration to image well the metabolites distribution.
|Titolo:||Transmit-only/receive-only radiofrequency system for Hyperpolarized 13C MRS cardiac metabolism studies in pigs|
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||1.1 Articolo su Rivista/Article|